Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.53 |
| ▸ | ESR1 | P03372 | 6/20 | 0.52 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.49 |
| ▸ | WIZ | O95785 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30619830 | 0.95 | CRBN (0.52) | CRBNESR1IKZF2WIZ | |
| SCHEMBL27302044 | 0.93 | CRBN (0.53) | CRBNESR1IKZF2WIZ | |
| SCHEMBL22951174 | 0.93 | CRBN (0.53) | CRBNESR1IKZF2WIZ | |
| SCHEMBL30942516 | 0.93 | CRBN (0.53) | CRBNESR1IKZF2WIZ | |
| SCHEMBL27194530 | 0.91 | CRBN (0.60) | CRBNESR1IKZF2WIZ | |
| SCHEMBL30144706 | 0.91 | CRBN (0.60) | CRBNESR1IKZF2WIZ | |
| Hydrochloric Acid SCHEMBL30828145 | 0.90 | CRBN (0.60) | CRBNESR1IKZF2WIZ | |
| Hydrochloric Acid SCHEMBL27194374 | 0.90 | CRBN (0.60) | CRBNESR1IKZF2WIZ | |
| SCHEMBL27314019 | 0.90 | CRBN (0.57) | CRBNESR1IKZF2WIZ | |
| SCHEMBL30619731 | 0.89 | CRBN (0.55) | CRBNESR1IKZF2WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12590079-B2 | Compounds and uses thereof | FOGHORN THERAPEUTICS INC. (US) | 2026-03-31 | — | — | US | disclosed |
| US-12391686-B2 | Compounds and uses thereof | FOGHORN THERAPEUTICS INC. (US) | 2025-08-19 | — | — | US | disclosed |
| US-20230077730-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-03-16 | — | — | US | disclosed |
| US-20220289711-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2022-09-15 | — | — | US | disclosed |
| EP-3917526-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2021022163-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-02-04 | — | — | WO | disclosed |
| WO-2021022163-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-02-04 | — | — | WO | disclosed |
| WO-2020160192-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12590079-B2 | Compounds and uses thereof | PSMB6, PSMC4, PSMB2 | CRBN 16/4885ESR1 2345/4885IKZF2 1865/4885 |
| US-20230077730-A1 | COMPOUNDS AND USES THEREOF | VHL, TFEB, BECN1 | CRBN 56/4885ESR1 1251/4885IKZF2 221/4885 |
| US-12391686-B2 | Compounds and uses thereof | VHL, TFEB, BECN1 | CRBN 56/4885ESR1 1251/4885IKZF2 221/4885 |
| US-20220289711-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | CRBN 179/4885ESR1 3083/4885IKZF2 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.