Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 7/20 | 0.54 |
| ▸ | NOS3 | P29474 | 4/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664694 | 0.89 | NOS1 (0.52) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL13381445 | 0.82 | NOS1 (0.50) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL5935352 | 0.78 | ADRA2A (0.44) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL10072502 | 0.78 | NOS1 (0.45) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL27747191 | 0.77 | NOS1 (0.60) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL5746645 | 0.74 | NOS1 (0.54) | NOS1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL19063477 | 0.72 | NOS1 (0.56) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL7448212 | 0.71 | NOS1 (1.00) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL3785375 | 0.71 | NOS1 (1.00) | NOS1NOS3HTR3EHTR3BHTR3A | |
| SCHEMBL6273560 | 0.71 | NOS1 (1.00) | NOS1NOS3HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710265-B2 | Switchable solvents and methods of use thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2014-04-29 | — | — | US | disclosed |
| US-20130327989-A1 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF | GEORGIA TECH RESEARCH CORPORATION (US) | 2013-12-12 | — | — | US | disclosed |
| US-8513464-B2 | Switchable solvents and methods of use thereof | GEORGIA TECH RESEARCH CORPORATION (US) | 2013-08-20 | — | — | US | disclosed |
| US-20130046092-A2 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2013-02-21 | — | — | US | disclosed |
| US-20120116076-A1 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF | GEORGIA TECH RESEARCH CORPORATION (US) | 2012-05-10 | — | — | US | disclosed |
| US-7982069-B2 | Amidine compound in water and/or alcohol; reversibly converts from nonionic to ionic liquid when contacted with trigger | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2011-07-19 | — | — | US | disclosed |
| US-20080058549-A1 | Switchable solvents and methods of use thereof | UNITED STATES DEPARTMENT OF ENERGY | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130046092-A2 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF | ALKBH1, CHRM1, GUCY1A2 | NOS1 51/4885NOS3 178/4885HTR3E 2237/4885 |
| US-20120116076-A1 | SWITCHABLE SOLVENTS AND METHODS OF USE THEREOF | ALKBH1, CHRM1, GUCY1A2 | NOS1 51/4885NOS3 178/4885HTR3E 2237/4885 |
| US-20080058549-A1 | Switchable solvents and methods of use thereof | ALKBH1, CHRM1, GUCY1A2 | NOS1 51/4885NOS3 178/4885HTR3E 2237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.