SCHEMBL2229798

SCHEMBL2229798

CC(C)(C)c1ccc2cnncc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.41
▸ HPGD P15428 1/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ MEN1 O00255 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ RECQL P46063 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ NR1I2 O75469 1/20 0.38
▸ TSHR P16473 1/20 0.37
▸ KCNH2 Q12809 2/20 0.37
▸ SCN10A Q9Y5Y9 2/20 0.37
▸ LMNA P02545 1/20 0.36
▸ TYR P14679 1/20 0.36
▸ KIF11 P52732 4/20 0.35
▸ NPC1 O15118 3/20 0.35
▸ RAB9A P51151 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL348347 0.80 ALDH1A1 (0.52) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL30010382 0.80 ALDH1A1 (0.52) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL14418567 0.79 MAPK1 (0.42) ALDH1A1MEN1MAPTKMT2AKCNH2
SCHEMBL22292142 0.78 SCN10A (0.39) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL31292303 0.78 SCN10A (0.40) ALDH1A1KCNH2SCN10A
SCHEMBL7521505 0.78 ALDH1A1 (0.50) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL30010643 0.78 ALDH1A1 (0.50) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL28105147 0.78 ALDH1A1 (0.50) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL27920310 0.77 BACE1 (0.50) MEN1KMT2ATSHRKIF11
SCHEMBL2627057 0.77 PRKCZ (0.46) ALDH1A1HPGDALOX15HSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 531 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6783927-B2 CONTAINING SURFACTANT FUJI PHOTO FILM, CO., LTD. (JP) 2004-08-31 — — US claimed
CN-110579936-B Thermally developable photosensitive material and medical film using the same 柯尼卡美能达株式会社 2023-10-27 — — CN disclosed
US-11672799-B2 1,4-disubstituted pyridazine quinolne analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2023-06-13 — — US disclosed
US-11672799-B2 1,4-disubstituted pyridazine quinolne analogs there of and methods for treating SMN-deficiency-related conditions NOVARTIS AG (CH) 2023-06-13 — — US disclosed
CN-110579936-A Heat-developable photosensitive material and medical film using the same 柯尼卡美能达株式会社 2019-12-17 — — CN disclosed
US-20180170923-A1 COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2018-06-21 — — US disclosed
EP-1072948-B1 Thermally processed image recording material FUJIFILM CORP (JP) 2017-07-05 — — EP disclosed
US-20170001995-A1 COMPOUNDS FOR THE TREATMENT OF CANCER HOFFMANN-LA ROCHE INC. (US) 2017-01-05 — — US disclosed
US-20160184305-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2016-06-30 — — US disclosed
US-9174974-B2 Macrocyclic factor VIIa inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2015-11-03 — — US disclosed
US-6165707-A Photothermographic or thermographic image-forming material FUJI PHOTO FILM CO., LTD. (JP) 2000-12-26 — — US disclosed
US-6156491-A Heat developable light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 2000-12-05 — — US disclosed
US-6150084-A NUCLEATING AGENT AND DIPHOSPHORUS PENTOXIDE-DERIVED COMPOUND; ANTIFOGGING AGENT, CONTRAST FUJI PHOTO FILM CO., LTD. (JP) 2000-11-21 — — US disclosed
EP-1045284-A1 Heat developing method for heat developable image recording material FUJI PHOTO FILM CO., LTD. (JP) 2000-10-18 — — EP disclosed
EP-1041433-A1 Heat-developable photosensitive material and method for forming image using the same FUJI PHOTO FILM CO., LTD. (JP) 2000-10-04 — — EP disclosed
EP-1041435-A1 Heat-developable photographic material FUJI PHOTO FILM CO., LTD. (JP) 2000-10-04 — — EP disclosed
EP-1041434-A1 Heat-developable photosensitive material FUJI PHOTO FILM CO., LTD. (JP) 2000-10-04 — — EP disclosed
US-6100022-A COMPRISES A NONPHOTOSENSITIVE ORGANIC SILVER SALT, A PHOTOSENSITIVE SILVER HALIDE AND A POLYMERIC BINDER HAVING GLASS TRANSITION TEMPERATURE OF-30 TO 40 DEGREE C. ON A SUPPORT, AND IMAGE FORMING LAYER CONTAINING NUCLEATING AGENT FUJI PHOTO FILM CO., LTD. (JP) 2000-08-08 — — US disclosed
EP-0990946-A1 Heat-developable photosensitive material FUJI PHOTO FILM CO., LTD. (JP) 2000-04-05 — — EP disclosed
EP-0962812-A1 Aqueous dispersion of fatty acid silver salt particles, method for redispersing fatty acid silver salt particles, photothermographic light-sensitive material, and method for producing the same FUJI PHOTO FILM CO., LTD. (JP) 1999-12-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180170923-A1 COMPOUNDS FOR THE TREATMENT OF CANCER FOXM1, SF3B1, SF3B5 ALDH1A1 336/4885HPGD 2399/4885ALOX15 1226/4885
US-20160184305-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, SCN5A, SF3B5 ALDH1A1 714/4885HPGD 1634/4885ALOX15 2323/4885
US-11672799-B2 1,4-disubstituted pyridazine quinolne analogs there of and methods for treating SMN-deficiency-related conditions SMN1; SMN2, CLN6, PMP22 ALDH1A1 741/4885HPGD 1812/4885ALOX15 2751/4885
US-20170001995-A1 COMPOUNDS FOR THE TREATMENT OF CANCER FOXM1, SF3B1, SF3B5 ALDH1A1 336/4885HPGD 2399/4885ALOX15 1226/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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