Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22299552 | 0.86 | SRC (0.68) | SRCPTPN1GSK3BMAPK1BCHE | |
| SCHEMBL22299950 | 0.86 | SRC (0.56) | SRCPTPN1GSK3BBCHEACHE | |
| SCHEMBL22299558 | 0.86 | ADRA2A (0.47) | SRCADRB2ADRB1ADRB3ADRA2A | |
| SCHEMBL21423114 | 0.79 | CA12 (0.47) | ADRB2ADRB1ADRB3ADRA2AADRA1A | |
| SCHEMBL12606793 | 0.75 | CA12 (0.50) | ADRB2ADRB1ADRB3ADRA2AADRA1A | |
| SCHEMBL11437277 | 0.75 | CA12 (0.50) | ADRB2ADRB1ADRB3ADRA2AADRA1A | |
| SCHEMBL10172021 | 0.75 | CA12 (0.50) | ADRB2ADRB1ADRB3ADRA2AADRA1A | |
| SCHEMBL22210841 | 0.75 | CA12 (0.43) | ADRA2AADRA1ACA12CA1CA2 | |
| SCHEMBL24313204 | 0.74 | CA12 (0.42) | ADRA2AADRA1ACA12CA1CA2 | |
| SCHEMBL932359 | 0.73 | ADRA1A (0.56) | ADRA2AADRA1ACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2022-04-07 | — | — | US | disclosed |
| WO-2020154811-A9 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-09-17 | — | — | WO | disclosed |
| WO-2020154811-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | Cava Healthcare Inc. (CA) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220105051-A1 | COMPOUNDS FOR INCREASING MHC-I EXPRESSION AND MODULATING HISTONE DEACETYLASE ACTIVITY | HDAC1, TAP1, HDAC11 | SRC 2561/4885PTPN1 2769/4885GSK3B 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.