Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24475353 | 0.90 | CYP1A2 (0.40) | HRH3TSHRGNAO1SIGMAR1CYP1A2 | |
| SCHEMBL26705116 | 0.88 | NCF1 (0.39) | HRH3GNAO1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL25090036 | 0.86 | TSHR (0.37) | HRH3TSHRGNAO1SIGMAR1CYP1A2 | |
| SCHEMBL27267884 | 0.85 | ACHE (0.37) | HRH3TSHRSIGMAR1EPHX1SMN1; SMN2 | |
| SCHEMBL22306420 | 0.83 | TSHR (0.36) | TSHRGNAO1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL1753483 | 0.82 | TSHR (0.46) | TSHR | |
| SCHEMBL22520648 | 0.80 | HRH3 (0.44) | HRH3GNAO1GNAI3GNAI1HSD11B1 | |
| SCHEMBL13061302 | 0.79 | GNAO1 (0.42) | HRH3GNAO1GNAI3GNAI1HSD11B1 | |
| SCHEMBL24754307 | 0.77 | NCF1 (0.45) | HRH3GNAO1GNAI3GNAI1HSD11B1 | |
| SCHEMBL7908231 | 0.77 | CYP1A2 (0.46) | HRH3GNAO1CYP1A2CYP2D6HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160198-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160196-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160193-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |