Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087689 | 1.00 | HTR1A (1.00) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL29389745 | 1.00 | HTR1A (1.00) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8445391 | 0.90 | ALDH1A1 (0.82) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442534 | 0.89 | HTR1A (0.80) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8445633 | 0.89 | HTR1A (0.79) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442467 | 0.88 | HTR1A (0.78) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9280040 | 0.87 | HTR1A (0.77) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8444594 | 0.87 | HTR1A (0.77) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8445766 | 0.87 | HTR1A (0.77) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8444593 | 0.87 | HTR1A (0.77) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11426408-B2 | Use of serotonergic drugs to treat virus-induced thrombocytopenia | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2022-08-30 | — | — | US | claimed |
| US-20200352947-A1 | USE OF SEROTONERGIC DRUGS TO TREAT VIRUS-INDUCED THROMBOCYTOPENIA | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-11-12 | — | — | US | claimed |
| US-20140350064-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AN AMPK ACTIVATOR AND A SEROTONERGIC AGENT AND METHODS OF USE THEREOF | ALS MOUNTAIN LLC | 2014-11-27 | — | — | US | claimed |
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| WO-2009090556-A2 | ARTIFICIAL REPRODUCTION OF PHARMACEUTICAL CONDITIONS OF DEPENDENCY TO TOBACCO AND OTHER ADDICTIVE DRUGS (OPIACEA, PSYCHOSTIMULANTS, ALCOHOL) BY COMBINATION OF NICOTINE AND A LIGAND (AGONIST OR 5 ANTAGONIST) OF 5-HT1A RECEPTORS | TASSIN, THOMAS (FR) | 2009-07-23 | — | — | WO | claimed |
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-04-14 | — | — | US | claimed |
| WO-2005018541-A2 | COX-2 INHIBITOR AND SEROTONIN MODULATOR FOR TREATING CNS DAMAGE | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | claimed |
| EP-0760665-B1 | COMPOSITIONS CONTAINING 5HTIA AND 5HTID ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-12 | — | — | EP | claimed |
| EP-0877612-B1 | USE OF PIPERAZINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | WYETH JOHN & BROTHER LTD (GB) | 2000-08-16 | — | — | EP | claimed |
| EP-0395313-B1 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PROD (US) | 1999-12-15 | — | — | EP | claimed |
| EP-0877612-A1 | USE OF PIPERAZINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1998-11-18 | — | — | EP | claimed |
| US-5827847-A | Treatment of cognitive disorders with piperazine derivatives | JOHN WYETH & BROTHER, LTD. (GB) | 1998-10-27 | — | — | US | claimed |
| WO-1996001656-A1 | 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1996-01-25 | — | — | WO | claimed |
| EP-0686047-A1 | 5-HT 1A? LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-13 | — | — | EP | claimed |
| WO-1994019026-A1 | 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-01 | — | — | WO | claimed |
| WO-1994009780-A1 | USE OF PIPERAZINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-05-11 | — | — | WO | claimed |
| US-11426408-B2 | Use of serotonergic drugs to treat virus-induced thrombocytopenia | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2022-08-30 | — | — | US | disclosed |
| US-20200352947-A1 | USE OF SEROTONERGIC DRUGS TO TREAT VIRUS-INDUCED THROMBOCYTOPENIA | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-11-12 | — | — | US | disclosed |
| WO-1994019026-A1 | 5-HT1A LIGANDS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-01 | — | — | WO | disclosed |
| WO-1994009780-A1 | USE OF PIPERAZINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080084-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage | TPH2, TPH1, HTR2A | HTR1A 6/4885ALDH1A1 1946/4885KDM4E 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.