SCHEMBL22306376

SCHEMBL22306376

N#CC(C#N)=CNCCCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.48
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
TAAR1 Q96RJ0 1/20 0.43
RAB9A P51151 2/20 0.42
GAA P10253 2/20 0.42
HPGD P15428 2/20 0.42
NPC1 O15118 1/20 0.42
KDM4E B2RXH2 1/20 0.42
JAK2 O60674 1/20 0.42
GMNN O75496 1/20 0.42
ALDH1A1 P00352 1/20 0.42
EGFR P00533 1/20 0.42
LMNA P02545 1/20 0.42
ERBB2 P04626 1/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.42
HSP90AA1 P07900 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3937741 0.79 ADH1B (0.48) MEN1KMT2AGAAHPGDKDM4E
SCHEMBL10937019 0.72 SIGMAR1 (0.55) SIGMAR1MEN1KMT2AL3MBTL1TAAR1
SCHEMBL10952837 0.71 ALDH1A1 (0.48) MEN1KMT2AL3MBTL1TAAR1RAB9A
SCHEMBL10952830 0.71 ALDH1A1 (0.48) MEN1KMT2AL3MBTL1TAAR1RAB9A
SCHEMBL8916941 0.71 SIGMAR1 (0.59) SIGMAR1MEN1KMT2AL3MBTL1HPGD
SCHEMBL19711877 0.71 SIGMAR1 (0.59) SIGMAR1MEN1KMT2AL3MBTL1HPGD
SCHEMBL1356645 0.71 SIGMAR1 (0.65) SIGMAR1MEN1KMT2AL3MBTL1
Hydrochloric Acid SCHEMBL2493107 0.69 SIGMAR1 (0.57) SIGMAR1MEN1KMT2AL3MBTL1HPGD
SCHEMBL9901355 0.69 GRIK1 (0.42) TAAR1HPGDALDH1A1CYP1A2ALOX15
Hydrochloric Acid SCHEMBL8171548 0.69 SIGMAR1 (0.57) SIGMAR1MEN1KMT2AL3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020156298-A1 APPLICATION OF MALONONITRILE COMPOUND AS BACTERICIDE 沈阳化工大学 2020-08-06 WO disclosed