Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26546886 | 0.76 | HSD11B1 (0.38) | HSD11B1 | |
| SCHEMBL22036800 | 0.75 | BRD4 (0.37) | SIGMAR1 | |
| SCHEMBL13684351 | 0.75 | GRM5 (0.34) | HSD11B1 | |
| SCHEMBL14488660 | 0.72 | LMNA (0.37) | HSD11B1 | |
| SCHEMBL29331615 | 0.68 | LIPE (0.33) | — | |
| SCHEMBL26080988 | 0.67 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL18806095 | 0.66 | TSHR (0.38) | HSD11B1 | |
| SCHEMBL22916075 | 0.66 | — | — | |
| SCHEMBL25771961 | 0.65 | SIGMAR1 (0.36) | OPRM1KCNH2SIGMAR1 | |
| SCHEMBL8064563 | 0.65 | CYP2D6 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | HSD11B1 3379/4885OPRM1 3858/4885KCNH2 3900/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | HSD11B1 2921/4885OPRM1 3512/4885KCNH2 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.