Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308443 | 0.79 | SMN1; SMN2 (0.45) | L3MBTL1MAPTGAASMN1; SMN2RAPGEF4 | |
| SCHEMBL22307381 | 0.79 | AKR1B1 (0.41) | KDM4EALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL22308264 | 0.77 | AKR1B1 (0.44) | ALDH1A1MAPTHTTGAAPOLB | |
| SCHEMBL22307379 | 0.73 | AKR1B1 (0.48) | ALDH1A1MAPTLMNAPOLBTP53 | |
| SCHEMBL22308629 | 0.71 | AKR1B1 (0.44) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL22308428 | 0.70 | ALDH1A1 (0.43) | KDM4EALDH1A1MAPTLMNATDP1 | |
| SCHEMBL22307378 | 0.68 | HDAC8 (0.47) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL29468592 | 0.68 | ALDH1A1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTHTT | |
| SCHEMBL475089 | 0.68 | ALDH1A1 (0.55) | L3MBTL1KDM4EALDH1A1MAPTHTT | |
| SCHEMBL22308352 | 0.68 | NR1I2 (0.39) | ALDH1A1MAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | L3MBTL1 1260/4885KDM4E 1414/4885ALDH1A1 3564/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | L3MBTL1 3380/4885KDM4E 2440/4885ALDH1A1 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.