Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308629 | 0.84 | AKR1B1 (0.44) | AKR1B1TP53ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL22308264 | 0.84 | AKR1B1 (0.44) | AKR1B1ALDH1A1SLC9A1PKMMEN1 | |
| SCHEMBL22307376 | 0.81 | AGTR1 (0.43) | AGTR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL22307873 | 0.81 | MAOA (0.40) | ALDH1A1PKMPIK3CAMAPT | |
| SCHEMBL22308428 | 0.81 | ALDH1A1 (0.43) | HTR6ALDH1A1HSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL22308585 | 0.79 | L3MBTL1 (0.37) | TP53ALDH1A1TDP1SMN1; SMN2KDM4E | |
| SCHEMBL22308350 | 0.78 | ALDH3A1 (0.34) | TDP1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL22308352 | 0.75 | NR1I2 (0.39) | AKR1B1ALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL8250024 | 0.75 | HTR6 (0.45) | AKR1B1HTR6TP53LGALS3AGTR1 | |
| SCHEMBL9915190 | 0.75 | HTR6 (0.45) | AKR1B1HTR6TP53LGALS3AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | AKR1B1 2660/4885HTR6 4530/4885TP53 14/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | AKR1B1 1943/4885HTR6 4803/4885TP53 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.