Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308443 | 0.78 | SMN1; SMN2 (0.45) | NR1I2MAPTSMN1; SMN2PKMGAA | |
| SCHEMBL22308264 | 0.75 | AKR1B1 (0.44) | NR1I2AKR1B1PTGS2MAPTPKM | |
| SCHEMBL22307381 | 0.75 | AKR1B1 (0.41) | AKR1B1MAPTSMN1; SMN2PKMALDH1A1 | |
| SCHEMBL22308629 | 0.72 | AKR1B1 (0.44) | AKR1B1PTGS2MAPTSMN1; SMN2PKM | |
| SCHEMBL22308428 | 0.72 | ALDH1A1 (0.43) | NR1I2PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL22308350 | 0.72 | ALDH3A1 (0.34) | NR1I2PTGS2SMN1; SMN2CA1CA2 | |
| SCHEMBL22308430 | 0.72 | CYP1B1 (0.58) | CYP1B1ALDH1A1 | |
| SCHEMBL22307873 | 0.69 | MAOA (0.40) | NR1I2MAPTPKMALDH1A1GAA | |
| SCHEMBL22307376 | 0.69 | AGTR1 (0.43) | PTGS2MAPTSMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL22308585 | 0.68 | L3MBTL1 (0.37) | MAPTSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358940-B2 | K-Ras modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200247762-A1 | K-RAS MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247762-A1 | K-RAS MODULATORS | KRAS, HRAS, NRAS | NR1I2 2549/4885F2 4806/4885AKR1B1 2660/4885 |
| US-11358940-B2 | K-Ras modulators | KRAS, HRAS, NRAS | NR1I2 1591/4885F2 3971/4885AKR1B1 1943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.