SCHEMBL22310690

SCHEMBL22310690

CC(CC(F)F)NC(=O)O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
FOLH1 Q04609 2/20 0.34
NAALAD2 Q9Y3Q0 2/20 0.34
ALDH1A1 P00352 2/20 0.34
MLYCD O95822 1/20 0.33
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
PKM P14618 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
TAS1R3 Q7RTX0 1/20 0.31
TAS1R1 Q7RTX1 1/20 0.31
TAS1R2 Q8TE23 1/20 0.31
MAPT P10636 1/20 0.31
MMP1 P03956 1/20 0.30
MMP2 P08253 1/20 0.30
MMP3 P08254 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28709191 0.85 CYP2D6 (0.42) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL6728949 0.80 ALDH1A1 (0.46) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL21462562 0.78 CYP2D6 (0.37) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL21462561 0.78 CYP2D6 (0.37) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL15201194 0.78 CYP2D6 (0.37) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL25275077 0.78 CYP2D6 (0.37) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL21462551 0.78 CYP2D6 (0.37) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL25354729 0.76 GABRP (0.39) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL15270313 0.74 TRPA1 (0.36) CYP2D6CYP2C19FOLH1NAALAD2ALDH1A1
SCHEMBL21813436 0.74 MTNR1A (0.35) CYP2D6CYP2C19FOLH1NAALAD2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020157652-A2 CDK2 INHIBITORS PFIZER INC. (US) 2020-08-06 WO disclosed