Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22311540 | 0.81 | KMT2A (0.54) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311542 | 0.79 | PKM (0.52) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311876 | 0.79 | PKM (0.52) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311548 | 0.75 | PKM (0.53) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311845 | 0.75 | ROCK2 (0.54) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311607 | 0.72 | KMT2A (0.55) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311011 | 0.72 | KMT2A (0.55) | PKMKMT2ARECQLHTTSMN1; SMN2 | |
| SCHEMBL22311610 | 0.72 | GAA (0.67) | KMT2AHTTSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL22311553 | 0.72 | GAA (0.67) | KMT2AHTTSMN1; SMN2LMNACYP3A4 | |
| SCHEMBL10311689 | 0.71 | PKM (0.73) | PKMKMT2ARECQLHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | AERIE PHARMACEUTICALS, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | ALCON INC. (CH) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | MYOC, HDAC8, PDE6C | PKM 2147/4885KMT2A 253/4885RECQL 1995/4885 |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | MYOC, HDAC8, PDE6C | PKM 2147/4885KMT2A 253/4885RECQL 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.