Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22311607 | 0.89 | KMT2A (0.55) | KMT2APKMRECQLLMNAMEN1 | |
| SCHEMBL22311011 | 0.89 | KMT2A (0.55) | KMT2APKMRECQLLMNAMEN1 | |
| SCHEMBL22311571 | 0.81 | PKM (0.52) | KMT2APKMRECQLLMNAALDH1A1 | |
| SCHEMBL8837212 | 0.79 | KMT2A (0.55) | KMT2APKMRECQLLMNAMEN1 | |
| SCHEMBL22311845 | 0.77 | ROCK2 (0.54) | KMT2APKMRECQLLMNAHTT | |
| SCHEMBL22311548 | 0.77 | PKM (0.53) | KMT2APKMRECQLLMNAALDH1A1 | |
| SCHEMBL22311542 | 0.76 | PKM (0.52) | KMT2APKMRECQLLMNAALDH1A1 | |
| SCHEMBL22311876 | 0.76 | PKM (0.52) | KMT2APKMRECQLLMNAALDH1A1 | |
| SCHEMBL15319936 | 0.76 | ALDH1A1 (0.73) | KMT2APKMRECQLLMNAMEN1 | |
| SCHEMBL10311689 | 0.73 | PKM (0.73) | KMT2APKMRECQLLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | AERIE PHARMACEUTICALS, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | ALCON INC. (CH) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | MYOC, HDAC8, PDE6C | KMT2A 253/4885PKM 2147/4885RECQL 1995/4885 |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | MYOC, HDAC8, PDE6C | KMT2A 253/4885PKM 2147/4885RECQL 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.