Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 0.76 |
| ▸ | AR | P10275 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluticasone SCHEMBL65401 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL14135286 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL4069 | 1.00 | NR3C1 (1.00) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL28888601 | 0.99 | NR3C1 (0.98) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL28821706 | 0.99 | NR3C1 (0.98) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL28935320 | 0.98 | NR3C1 (0.97) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL27674669 | 0.97 | NR3C1 (0.95) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL896670 | 0.97 | NR3C1 (0.93) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL29113054 | 0.96 | NR3C1 (0.92) | NR3C1PGRARCYP3A4HIF1A | |
| Fluticasone SCHEMBL3365958 | 0.95 | NR3C1 (0.91) | NR3C1PGRARCYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7972626-B2 | Fluticasone powders has specific particle size distribution; increase bioavailability, prolonged therapeutic effect of the drug substance; aqueous suspension for inhalation; drug delivery method and device; rhinitis treatment | MERCK PATENT GMBH (DE) | 2011-07-05 | — | — | US | disclosed |
| US-20060051299-A1 | Nasal pharmaceutical formulations and methods of using the same | MERCK PATENT GMBH | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060051299-A1 | Nasal pharmaceutical formulations and methods of using the same | NR3C1, MC2R, NR3C2 | NR3C1 1/4885PGR 423/4885AR 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.