Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluticasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.73 |
| ▸ | PGR | P06401 | 5/20 | 0.73 |
| ▸ | AR | P10275 | 5/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.70 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluticasone SCHEMBL14135286 | 0.97 | NR3C1 (1.00) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL2231799 | 0.97 | NR3C1 (1.00) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL65401 | 0.97 | NR3C1 (1.00) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL4069 | 0.97 | NR3C1 (1.00) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL28821706 | 0.97 | NR3C1 (0.98) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL28888601 | 0.97 | NR3C1 (0.98) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL896670 | 0.96 | NR3C1 (0.93) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL28935320 | 0.96 | NR3C1 (0.97) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL3365958 | 0.94 | NR3C1 (0.91) | NR3C1CYP3A4PGRARHIF1A | |
| Fluticasone SCHEMBL28768408 | 0.94 | NR3C1 (0.91) | NR3C1CYP3A4PGRARHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119424589-A | Nasal preparation for treating rhinitis and preparation method and application thereof | 广州市训方医药科技有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-115212231-B | Methods and reagents for modulating immune modulating function of mesenchymal stem cells | 中国科学院上海营养与健康研究所 | 2024-12-31 | — | — | CN | disclosed |
| CN-115768402-A | 5-amino-2,3-dihydro-1,4-phthalazinedione for the treatment of acute lung injury | 麦翠奥制药公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-115337254-A | Intravitreal drug delivery system for treating ocular diseases | 爱瑞制药公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-111757764-B | System, kit and method for loading and delivering small volume doses from a syringe | 爱康生物科学股份有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-114786775-A | Methods of treating COPD by administering IL-33 antagonists | 赛诺菲生物技术公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114207440-A | PEGylated uricase formulations and dosages | 西莱克塔生物科技公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114144177-A | Antiarrhythmic formulations | 英凯达治疗公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-111757764-A | System, kit and method for loading and delivering small volume doses from a syringe | 爱康生物科学股份有限公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-110612122-A | Methods and compositions related to combination therapy with anti-inflammatory agents and synthetic nanocarriers comprising immunosuppressants | 西莱克塔生物科技公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-100497367-C | Synthesizing process of fluorine propionate ticasone | ZHAOKANG PHARMACEUTICAL CO LTD (CN) | 2009-06-10 | — | — | CN | disclosed |
| CN-100999541-A | Synthesizing process of fluorine propionate ticasone | ZHAOKANG PHARMACEUTICAL CO LTD (CN) | 2007-07-18 | — | — | CN | disclosed |