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Diclosulam

Diclosulam

SCHEMBL2231960

CCOc1nc(F)cc2nc(S(=O)(=O)Nc3c(Cl)cccc3C(=O)OC)nn12.CCOc1nc(F)cc2nc(S(=O)(=O)Nc3c(Cl)cccc3Cl)nn12

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 1/20 0.33
▸ MAPT P10636 2/20 0.33
▸ SCN9A Q15858 1/20 0.33
▸ AURKA O14965 1/20 0.33
▸ AURKB Q96GD4 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ POLB P06746 1/20 0.33
▸ MCOLN3 Q8TDD5 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ WDR5 P61964 1/20 0.33
▸ LMNA P02545 1/20 0.32
▸ MAPK1 P28482 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ RORC P51449 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30416435 0.99 CA2 (0.34) CA2MAPTSCN9AAURKAAURKB
SCHEMBL64266 0.99 CA2 (0.34) CA2MAPTSCN9AAURKAAURKB
Pyrimidine SCHEMBL27866314 0.94 SCN9A (0.33) CA2MAPTSCN9AAURKAAURKB
SCHEMBL18643336 0.93 CA2 (0.40) CA2MAPTAURKAAURKBALDH1A1
SCHEMBL118467 0.91 WDR5 (0.39) ALDH1A1WDR5
SCHEMBL4890265 0.91 WDR5 (0.39) ALDH1A1WDR5
SCHEMBL8113251 0.91 LMNA (0.37) ALDH1A1TP53KMT2AL3MBTL1LMNA
Diclosulam SCHEMBL116344 0.91 GNRHR (0.35) ALDH1A1LMNATSHR
SCHEMBL8113240 0.90 LMNA (0.36) MAPTALDH1A1LMNAMAPK1TSHR
SCHEMBL8848572 0.86 GNRHR (0.34) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2529028-A1 POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES ASSOCIATED WITH HERBICIDE TOLERANCE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2012-12-05 — — EP disclosed
EP-2529027-A1 HPPD-INHIBITOR HERBICIDE TOLERANCE Pioneer-Hi-Bred International, Inc. (US) 2012-12-05 — — EP disclosed
WO-2011094199-A1 POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES ASSOCIATED WITH HERBICIDE TOLERANCE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2011-08-04 — — WO disclosed
WO-2011094205-A1 HPPD-INHIBITOR HERBICIDE TOLERANCE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2011-08-04 — — WO disclosed