Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25258769 | 0.81 | SMN1; SMN2 (0.52) | ALDH1A1KDM4EKMT2AHTR3AHRH4 | |
| SCHEMBL4645058 | 0.78 | ALDH1A1 (0.46) | ALDH1A1ALDH1A3KDM4EAOX1TSHR | |
| SCHEMBL30531446 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EKMT2ANPSR1 | |
| SCHEMBL22322095 | 0.77 | HRH4 (0.35) | KMT2AHRH4TSHR | |
| SCHEMBL2390994 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4EKMT2AAOX1TSHR | |
| SCHEMBL23064621 | 0.73 | SMN1; SMN2 (0.50) | ALDH1A1KMT2ATSHRGAANPSR1 | |
| SCHEMBL16553207 | 0.72 | NFE2L2 (0.64) | ALDH1A1KDM4EKMT2ATSHRGAA | |
| SCHEMBL16553208 | 0.72 | NFE2L2 (0.64) | ALDH1A1KDM4EKMT2ATSHRGAA | |
| SCHEMBL4645229 | 0.71 | ALDH1A1 (0.45) | ALDH1A1ALDH1A3KDM4EKMT2AAOX1 | |
| SCHEMBL25313919 | 0.71 | GABRP (0.40) | HRH4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3921319-A1 | IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST | BeiGene, Ltd. (KY) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020160710-A1 | IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST | BEIGENE, LTD. (KY) | 2020-08-13 | — | — | WO | disclosed |