SCHEMBL22326117

SCHEMBL22326117

Cc1cc(C(c2cc(C)c(N)c(C)c2)C(F)(F)F)cc(C)c1N

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
TP53 P04637 2/20 0.44
CYP3A4 P08684 2/20 0.44
TSHR P16473 1/20 0.44
POLB P06746 1/20 0.43
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
THRB P10828 1/20 0.31
ALOX15 P16050 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CD44 P16070 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24332735 0.81 ESR1 (0.41) ESR1ESR2
SCHEMBL25210957 0.80 SMN1; SMN2 (0.42) ALDH1A1TSHRPOLBESR1ESR2
SCHEMBL30429057 0.79 GAA (0.50) ALDH1A1TP53TSHRESR1ESR2
SCHEMBL24190794 0.79 GAA (0.50) ALDH1A1TP53TSHRESR1ESR2
SCHEMBL26327918 0.79 AR (0.33) ALDH1A1POLBESR1ESR2GAA
SCHEMBL11052697 0.79 CA1 (0.46) ALDH1A1CYP3A4ESR1ESR2GAA
SCHEMBL1814835 0.78 ALDH1A1 (0.41) ALDH1A1TDP1TP53CYP3A4TSHR
SCHEMBL22326124 0.77 CYP3A4 (0.45) ALDH1A1TDP1TP53CYP3A4TSHR
SCHEMBL28024757 0.74 ESR1 (0.39) ESR1ESR2
SCHEMBL25626816 0.74 ESR1 (0.35) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US claimed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO claimed
CN-104829853-A Polyimide gas separation membrane as well as preparation method and applications thereof CHINESE ACAD INST CHEMISTRY 2015-08-12 CN claimed
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 US disclosed
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2025-07-08 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
WO-2023190187-A1 MALEIMIDE COMPOUND, MALEAMIC ACID COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, METHOD FOR PRODUCING MALEIMIDE COMPOUND AND METHOD FOR PRODUCING MALEAMIC ACID COMPOUND セントラル硝子株式会社 2023-10-05 WO disclosed
WO-2023190187-A1 MALEIMIDE COMPOUND, MALEAMIC ACID COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, METHOD FOR PRODUCING MALEIMIDE COMPOUND AND METHOD FOR PRODUCING MALEAMIC ACID COMPOUND セントラル硝子株式会社 2023-10-05 WO disclosed
WO-2023182141-A1 EPOXY COMPOUND, EPOXY RESIN, EPOXY RESIN COMPOSITION, CURED PRODUCT, PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL, PRODUCING METHODS THEREFOR, SEALING MATERIAL, SEMICONDUCTOR DEVICE, METHOD FOR SEALING SEMICONDUCTOR ELEMENT, AND METHOD FOR USING SAME AS SEALING MATERIAL セントラル硝子株式会社 2023-09-28 WO disclosed
EP-4163319-A1 POLYAMIDE, POLYAMIDE-IMIDE, DERIVATIVES OF THESE, OPTICAL FILM, DISPLAY DEVICE, AND PRODUCTION METHODS THEREFOR Central Glass Company, Limited (JP) 2023-04-12 EP disclosed
US-20220119595-A1 Polyamide Acid, Polyimide, Optical Film, Display Device and Production Methods Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-21 US disclosed
US-20220119595-A1 Polyamide Acid, Polyimide, Optical Film, Display Device and Production Methods Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-21 US disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US disclosed
WO-2020162411-A1 POLYAMIDE ACID, POLYIMIDE, OPTICAL FILM, DISPLAY DEVICE AND PRODUCTION METHODS OF THOSE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
CN-104829853-B A kind of polyimide gas separating film and preparation method and application 中国科学院化学研究所 2017-12-12 CN disclosed
CN-104829853-A Polyimide gas separation membrane as well as preparation method and applications thereof CHINESE ACAD INST CHEMISTRY 2015-08-12 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 ALDH1A1 624/4885TDP1 349/4885TP53 3544/4885
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof PUF60, PARG, TET3 ALDH1A1 3041/4885TDP1 2193/4885TP53 4549/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 ALDH1A1 624/4885TDP1 349/4885TP53 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.