SCHEMBL22326124

SCHEMBL22326124

Cc1cc(C(c2ccc(N)c(C)c2)C(F)(F)F)ccc1N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.45
TDP1 Q9NUW8 7/20 0.45
ALDH1A1 P00352 5/20 0.45
TSHR P16473 3/20 0.45
ESR1 P03372 3/20 0.43
ESR2 Q92731 2/20 0.43
S100B P04271 1/20 0.40
AR P10275 1/20 0.40
THRB P10828 3/20 0.38
HIF1A Q16665 2/20 0.38
ALOX15 P16050 2/20 0.38
RECQL P46063 1/20 0.38
SKP2 Q13309 1/20 0.35
MAPK1 P28482 2/20 0.34
GAA P10253 2/20 0.34
ALOX12 P18054 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
TP53 P04637 2/20 0.33
RAD52 P43351 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22337433 0.93 ESR1 (0.42) CYP3A4TDP1ALDH1A1TSHRESR1
SCHEMBL3277990 0.84 CYP3A4 (0.45) CYP3A4TDP1ALDH1A1TSHRESR1
SCHEMBL13703416 0.81 ESR1 (0.48) TDP1ALDH1A1TSHRESR1ESR2
SCHEMBL19179645 0.81 CYP3A4 (0.42) CYP3A4TDP1ALDH1A1TSHRESR1
SCHEMBL4195171 0.79 CYP3A4 (0.41) CYP3A4TDP1ALDH1A1TSHRESR1
SCHEMBL23005780 0.78 ESR1 (0.50) CYP3A4TDP1ALDH1A1TSHRESR1
SCHEMBL22326111 0.78 ALDH1A1 (0.46) ALDH1A1ESR1ESR2HIF1AGAA
SCHEMBL11050693 0.78 ESR1 (0.50) CYP3A4TDP1ALDH1A1ESR1ESR2
SCHEMBL22326133 0.77 ESR1 (0.41) TDP1ALDH1A1TSHRESR1ESR2
SCHEMBL22326117 0.77 ALDH1A1 (0.44) CYP3A4TDP1ALDH1A1TSHRESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US claimed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO claimed
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 US disclosed
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2025-07-08 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
US-20230323030-A1 Polyamide, Polyamide-Imide, Derivatives of These, Optical Film, Display Device, and Production Methods Therefor CENTRAL GLASS COMPANY, LIMITED (JP) 2023-10-12 US disclosed
WO-2023190187-A1 MALEIMIDE COMPOUND, MALEAMIC ACID COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, METHOD FOR PRODUCING MALEIMIDE COMPOUND AND METHOD FOR PRODUCING MALEAMIC ACID COMPOUND セントラル硝子株式会社 2023-10-05 WO disclosed
WO-2023190187-A1 MALEIMIDE COMPOUND, MALEAMIC ACID COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, METHOD FOR PRODUCING MALEIMIDE COMPOUND AND METHOD FOR PRODUCING MALEAMIC ACID COMPOUND セントラル硝子株式会社 2023-10-05 WO disclosed
WO-2023182141-A1 EPOXY COMPOUND, EPOXY RESIN, EPOXY RESIN COMPOSITION, CURED PRODUCT, PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL, PRODUCING METHODS THEREFOR, SEALING MATERIAL, SEMICONDUCTOR DEVICE, METHOD FOR SEALING SEMICONDUCTOR ELEMENT, AND METHOD FOR USING SAME AS SEALING MATERIAL セントラル硝子株式会社 2023-09-28 WO disclosed
US-20230287178-A1 Fluorinated Diamine or Salt Thereof, Method for Producing Fluorinated Diamine or Salt Thereof, Polyamide, Method for Producing Polyamide, Polyamide Solution, Cyclized Polyamide, Method for Producing Cyclized Polyamide, Insulation for High-Frequency Electronic Component, Method for Producing Insulation for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Appliance, and Insulating Material for Producing High-Frequency Electronic Component CENTRAL GLASS COMPANY, LIMITED (JP) 2023-09-14 US disclosed
US-20230287178-A1 Fluorinated Diamine or Salt Thereof, Method for Producing Fluorinated Diamine or Salt Thereof, Polyamide, Method for Producing Polyamide, Polyamide Solution, Cyclized Polyamide, Method for Producing Cyclized Polyamide, Insulation for High-Frequency Electronic Component, Method for Producing Insulation for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Appliance, and Insulating Material for Producing High-Frequency Electronic Component CENTRAL GLASS COMPANY, LIMITED (JP) 2023-09-14 US disclosed
EP-4190768-A1 FLUORINATED DIAMINE OR SALT THEREOF, METHOD FOR PRODUCING FLUORINATED DIAMINE OR SALT THEREOF, POLYAMIDE, METHOD FOR PRODUCING POLYAMIDE, POLYAMIDE SOLUTION, CYCLIZED POLYAMIDE, METHOD FOR PRODUCING CYCLIZED POLYAMIDE, INSULATING MATERIAL FOR HIGH-FREQUENCY ELECTRONIC COMPONENT, METHOD FOR PRODUCING INSULATING MATERIAL FOR HIGH-FREQUENCY ELECTRONIC COMPONENT, HIGH-FREQUENCY ELECTRONIC COMPONENT, HIGH-FREQUENCY APPLIANCE, AND INSULATING MATERIAL FOR PRODUCING HIGH-FREQUENCY ELECTRONIC COMPONENT Central Glass Company, Limited (JP) 2023-06-07 EP disclosed
EP-4190768-A1 FLUORINATED DIAMINE OR SALT THEREOF, METHOD FOR PRODUCING FLUORINATED DIAMINE OR SALT THEREOF, POLYAMIDE, METHOD FOR PRODUCING POLYAMIDE, POLYAMIDE SOLUTION, CYCLIZED POLYAMIDE, METHOD FOR PRODUCING CYCLIZED POLYAMIDE, INSULATING MATERIAL FOR HIGH-FREQUENCY ELECTRONIC COMPONENT, METHOD FOR PRODUCING INSULATING MATERIAL FOR HIGH-FREQUENCY ELECTRONIC COMPONENT, HIGH-FREQUENCY ELECTRONIC COMPONENT, HIGH-FREQUENCY APPLIANCE, AND INSULATING MATERIAL FOR PRODUCING HIGH-FREQUENCY ELECTRONIC COMPONENT Central Glass Company, Limited (JP) 2023-06-07 EP disclosed
EP-4163319-A1 POLYAMIDE, POLYAMIDE-IMIDE, DERIVATIVES OF THESE, OPTICAL FILM, DISPLAY DEVICE, AND PRODUCTION METHODS THEREFOR Central Glass Company, Limited (JP) 2023-04-12 EP disclosed
US-20220119595-A1 Polyamide Acid, Polyimide, Optical Film, Display Device and Production Methods Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-21 US disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 US disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 WO disclosed
WO-2020162411-A1 POLYAMIDE ACID, POLYIMIDE, OPTICAL FILM, DISPLAY DEVICE AND PRODUCTION METHODS OF THOSE セントラル硝子株式会社 2020-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 CYP3A4 1051/4885TDP1 349/4885ALDH1A1 624/4885
US-12351685-B2 Polyamide acid, polyimide, optical film, display device and production methods thereof PUF60, PARG, TET3 CYP3A4 4134/4885TDP1 2193/4885ALDH1A1 3041/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 CYP3A4 1051/4885TDP1 349/4885ALDH1A1 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.