Sugi Predict

Sugi Predict / Compounds / SCHEMBL22326133

SCHEMBL22326133

SCHEMBL22326133

CC(C)c1cc(C(c2ccc(N)c(C(C)C)c2)C(F)(F)F)ccc1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 1/20 0.41
▸ ESR2 Q92731 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.40
▸ GAA P10253 2/20 0.40
▸ HIF1A Q16665 2/20 0.40
▸ ALOX12 P18054 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ PDE2A O00408 1/20 0.34
▸ GABRA1 P14867 1/20 0.33
▸ GABRB2 P47870 1/20 0.33
▸ ALOX15 P16050 2/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ RECQL P46063 4/20 0.31
▸ TDP1 Q9NUW8 4/20 0.31
▸ KDM4E B2RXH2 4/20 0.31
▸ MAPT P10636 3/20 0.31
▸ LMNA P02545 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2199068 0.80 ALDH1A1 (0.54) ALDH1A1GAAHIF1AALOX12HTT
SCHEMBL2170424 0.78 GAA (0.42) ESR1ESR2ALDH1A1GAAHIF1A
Bromide SCHEMBL28948703 0.78 ALDH1A1 (0.52) ALDH1A1GAAHIF1AALOX12HTT
SCHEMBL22326124 0.77 CYP3A4 (0.45) ESR1ESR2ALDH1A1GAAHIF1A
SCHEMBL24190950 0.76 GABRA1 (0.44) ESR1ESR2ALDH1A1GAAHIF1A
SCHEMBL30428089 0.76 GABRA1 (0.44) ESR1ESR2ALDH1A1GAAHIF1A
SCHEMBL22326111 0.75 ALDH1A1 (0.46) ESR1ESR2ALDH1A1GAAHIF1A
SCHEMBL22068493 0.75 GAA (0.39) ALDH1A1GAAHIF1AALOX12HTT
SCHEMBL9818597 0.75 ALDH1A1 (0.48) ALDH1A1GAAHIF1AALOX12HTT
SCHEMBL23005780 0.75 ESR1 (0.50) ESR1ESR2ALDH1A1GAAHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 — — US disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 — — US disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 — — WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885ALDH1A1 624/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885ALDH1A1 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.