Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.46 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | AHCY | P23526 | 1/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22326729 | 0.82 | ADORA2A (0.66) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL18520987 | 0.79 | HTT (0.58) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL21137281 | 0.78 | CDK1 (0.57) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL18520056 | 0.76 | YTHDC1 (0.61) | HTTADORA2AADORA1TMIGD3PKM | |
| SCHEMBL18510350 | 0.75 | CDK1 (0.71) | HTTADORA2AADORA1ADORA2BCCNB2 | |
| SCHEMBL21943153 | 0.73 | CDK1 (0.61) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL29371602 | 0.70 | CYP3A4 (0.53) | HTTPKMCDK1ALDH1A1RAB9A | |
| SCHEMBL22326727 | 0.70 | ADORA2A (0.69) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL14479818 | 0.69 | CCNB2 (0.48) | HTTADORA2AADORA1TMIGD3ADORA2B | |
| SCHEMBL29389154 | 0.69 | CCNB2 (0.48) | HTTADORA2AADORA1TMIGD3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | STING1, CGAS, IFNAR1 | HTT 4646/4885ADORA2A 72/4885ADORA1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.