SCHEMBL22327062

SCHEMBL22327062

CC(C)CO[C@@H]1C[C@H](n2cc(C#CCNC(=O)C(F)(F)F)c(N)nc2=O)OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ POLG P54098 2/20 0.44
▸ P2RY2 P41231 6/20 0.36
▸ P2RY4 P51582 4/20 0.36
▸ P2RY6 Q15077 3/20 0.35
▸ POLB P06746 1/20 0.35
▸ POLA1 P09884 1/20 0.35
▸ POLD1 P28340 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26068621 0.94 POLG (0.42) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL30083115 0.89 POLG (0.47) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL22327251 0.89 POLG (0.46) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL24972855 0.88 POLG (0.41) POLGP2RY2P2RY4P2RY6
SCHEMBL22327013 0.87 ENTPD1 (0.38) POLB
SCHEMBL26068617 0.87 FUT5 (0.38) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL22327007 0.87 FUT5 (0.38) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL22327104 0.86 POLB (0.47) POLBPOLA1POLD1
SCHEMBL26068740 0.81 POLG (0.41) POLGP2RY2P2RY4P2RY6POLB
SCHEMBL24858810 0.81 POLG (0.43) POLGP2RY2P2RY4P2RY6POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10738072-B1 Nucleotide analogues Singular Genomics Systems, Inc. (US) 2020-08-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10738072-B1 Nucleotide analogues NUDT1, POLN, TYMP POLG 81/4885P2RY2 1236/4885P2RY4 833/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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