SCHEMBL26068617

SCHEMBL26068617

CC(C)COC1C[C@H](n2cc(C#CCNC(=O)C(F)(F)F)c3c(=O)[nH]c(N)nc32)O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ FUT5 Q11128 1/20 0.38
▸ POLB P06746 2/20 0.38
▸ KRAS P01116 4/20 0.37
▸ POLA1 P09884 1/20 0.37
▸ POLD1 P28340 1/20 0.37
▸ P2RY2 P41231 1/20 0.37
▸ P2RY4 P51582 1/20 0.37
▸ P2RY6 Q15077 1/20 0.37
▸ TGM2 P21980 1/20 0.35
▸ POLG P54098 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22327007 1.00 FUT5 (0.38) FUT5POLBKRASPOLA1POLD1
SCHEMBL24971484 0.93 FUT5 (0.39) FUT5POLBKRASPOLA1POLD1
SCHEMBL22327091 0.90 FUT5 (0.41) FUT5POLBKRASPOLA1POLD1
SCHEMBL22327062 0.87 POLG (0.44) POLBPOLA1POLD1P2RY2P2RY4
SCHEMBL22327104 0.87 POLB (0.47) POLBPOLA1POLD1
SCHEMBL22327013 0.87 ENTPD1 (0.38) POLB
SCHEMBL22327254 0.83 FUT5 (0.38) FUT5POLBKRASPOLA1POLD1
SCHEMBL22327234 0.83 FUT5 (0.38) FUT5POLBKRASPOLA1POLD1
SCHEMBL17225222 0.82 POLB (0.44) FUT5POLBKRASPOLA1POLD1
SCHEMBL26068621 0.81 POLG (0.42) POLBPOLA1POLD1P2RY2P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230257414-A1 NUCLEOTIDE ANALOGUES FIRST-CITIZENS BANK & TRUST COMPANY 2023-08-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257414-A1 NUCLEOTIDE ANALOGUES ITPA, POLB, NUDT1 FUT5 1476/4885POLB 2/4885KRAS 1117/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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