SCHEMBL2232893

SCHEMBL2232893

NCC(=O)c1nc2c(N)ncnc2n1[C@H]1C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ TRPM2 O94759 1/20 0.61
▸ POLB P06746 1/20 0.55
▸ ENTPD1 P49961 3/20 0.53
▸ ENPP1 P22413 1/20 0.50
▸ P2RY1 P47900 1/20 0.50
▸ P2RX1 P51575 1/20 0.49
▸ P2RX3 P56373 1/20 0.49
▸ P2RX2 Q9UBL9 1/20 0.49
▸ DTYMK P23919 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7644549 0.87 TRPM2 (0.65) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL30134675 0.86 TRPM2 (0.64) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL1063721 0.86 TRPM2 (0.64) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL12932270 0.86 TRPM2 (0.64) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL7648504 0.86 TRPM2 (0.64) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL15704019 0.83 TRPM2 (0.60) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL15715797 0.83 TRPM2 (0.60) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL1509270 0.83 TRPM2 (0.60) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL1887064 0.81 TRPM2 (0.56) TRPM2POLBENTPD1ENPP1P2RY1
SCHEMBL7042426 0.81 TRPM2 (0.56) TRPM2POLBENTPD1ENPP1P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8758995-B2 Solid phase sequencing of biopolymers SEQUENOM, INC. (US) 2014-06-24 — — US disclosed
US-20110172111-A1 SOLID PHASE SEQUENCING OF BIOPOLYMERS SEQUENOM, INC. (US) 2011-07-14 — — US disclosed
US-7803529-B1 Solid phase sequencing of biopolymers SEQUENOM, INC. (US) 2010-09-28 — — US disclosed
US-20060063193-A1 Solid phase sequencing of double-stranded nucleic acids TRUSTEES OF BOSTON UNIVERSITY, THE 2006-03-23 — — US disclosed
US-6991903-B2 Solid phase sequencing of double-stranded nucleic acids SEQUENOM, INC. (US) 2006-01-31 — — US disclosed
US-20040126772-A1 Method for maldi-tof-ms analysis and/or sequencing of oligonucleotides RIKEN (JP) 2004-07-01 — — US disclosed
EP-0679196-B1 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM INC (US) 2004-05-26 — — EP disclosed
EP-1364058-A2 METHOD FOR MALDI-TOF-MS ANALYSIS AND/OR SEQUENCING OF OLIGONUCLEOTIDES Riken (JP) 2003-11-26 — — EP disclosed
US-20030096258-A1 Sequencing target nucleic acid; obtain single stranded nucleotide sequences, incubate with denatured nucleotide sequences, amplify determining sequence of nucleotide sequence TRUSTEES OF BOSTON UNIVERSITY, THE 2003-05-22 — — US disclosed
EP-1262564-A2 Dna sequencing by mass spectrometry SEQUENOM, INC. (US) 2002-12-04 — — EP disclosed
WO-1997037041-A9 DNA SEQUENCING BY MASS SPECTROMETRY — 1997-12-31 — — WO disclosed
US-5691141-A SOLID PHASE SYNTHESIS, LINKING LARGE MOLECULES TO NUCLEOTIDES TO DIFFERENTIATE SEQUENOM, INC. (US) 1997-11-25 — — US disclosed
WO-1997037041-A2 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM, INC. (US) 1997-10-09 — — WO disclosed
US-5622824-A CLEAVING NUCLEIC ACID UNILATERALLY FROM FIRST END WITH EXONUCLEASE ACTIVITY TO RELEASE INDIVISUAL NUCLEOTIDES, IDENTIFYING RELEASED NUCLEOTIDES WITH MASS SPECTROSCOPY SEQUENOM, INC. (US) 1997-04-22 — — US disclosed
WO-1996032504-A2 SOLID PHASE SEQUENCING OF BIOPOLYMERS TRUSTEES OF BOSTON UNIVERSITY (US) 1996-10-17 — — WO disclosed
US-5547835-A USING THE SANGER SEQUENCING STRATEGY AND ASSEMBLING THE SEQUENCE INFORMATION BY ANALYSIS OF THE NESTED FRAGMENTS OBTAINED BY BASE-SPECIFIC CHAIN TERMINATION VIA THEIR DIFFERENT MOLECULAR MASSES SEQUENOM, INC. (US) 1996-08-20 — — US disclosed
EP-0689610-A1 DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION SEQUENOM, INC. (US) 1996-01-03 — — EP disclosed
EP-0679196-A1 DNA SEQUENCING BY MASS SPECTROMETRY SEQUENOM, INC. (US) 1995-11-02 — — EP disclosed
WO-1994021822-A1 DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION SEQUENOM, INC. (US) 1994-09-29 — — WO disclosed
WO-1994016101-A2 DNA SEQUENCING BY MASS SPECTROMETRY KOESTER HUBERT (US) 1994-07-21 — — WO disclosed
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