SCHEMBL2233473

SCHEMBL2233473

CCc1ccc2c(c1-c1ccccc1OC)C=C(c1cc(C)c(C)o1)C2[Zr](Cl)(Cl)(C1C(c2cc(C)c(C)o2)=Cc2c1ccc(CC)c2-c1ccccc1OC)=[Si](C)C

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FPR1 P21462 6/20 0.37
S1PR4 O95977 1/20 0.31
PTGER4 P35408 1/20 0.31
ALDH1A1 P00352 2/20 0.30
TSHR P16473 1/20 0.30
KDM4E B2RXH2 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2235699 0.91
SCHEMBL2238097 0.91
SCHEMBL2233397 0.90 KDM4E (0.30) FPR1ALDH1A1KDM4ECYP3A4MAPT
SCHEMBL2236199 0.89 S1PR4 (0.34) S1PR4
SCHEMBL2386122 0.88 HTR2C (0.31)
SCHEMBL2235065 0.88 FPR1 (0.34) FPR1ALDH1A1KDM4EMAPTHPGD
SCHEMBL2236997 0.86
SCHEMBL2235167 0.85
SCHEMBL2236915 0.85 FPR1 (0.35) FPR1S1PR4PTGER4ALDH1A1KDM4E
SCHEMBL2237796 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2360163-B1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN JAPAN POLYPROPYLENE CORP (JP) 2014-06-25 EP disclosed
US-8461365-B2 Metallocene complex and polymerization method of olefin JAPAN POLYPROPYLENE CORPORATION (JP) 2013-06-11 US disclosed
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN JAPAN POLYPROPYLENE CORPORATION (JP) 2011-09-22 US disclosed
EP-2360163-A1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN Japan Polypropylene Corporation (JP) 2011-08-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN ALOX12, ALOX15, ALOX15B FPR1 1761/4885S1PR4 2768/4885PTGER4 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.