Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22335733 | 0.97 | KDM4E (0.48) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL11085849 | 0.85 | MAPT (0.49) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL20892324 | 0.82 | HPGD (0.55) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL31563949 | 0.81 | MEN1 (0.40) | HPGDMAPTKDM4ELMNANPC1 | |
| SCHEMBL11082934 | 0.80 | MAPT (0.45) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL11082944 | 0.80 | MAPT (0.45) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL1858733 | 0.80 | S1PR1 (0.42) | KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23335496 | 0.79 | TP53 (0.51) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL26954393 | 0.78 | MEN1 (0.52) | HPGDTP53MAPTKDM4ELMNA | |
| SCHEMBL22678755 | 0.77 | FABP4 (0.41) | HPGDMAPTKDM4ELMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124523-B2 | 2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof | SHANDONG LUYE PHARMACEUTICAL CO., LTD. | 2021-09-21 | — | — | US | disclosed |
| US-20200255444-A1 | 2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF | SHANDONG LUYE PHARMACEUTICAL CO., LTD. (CN) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255444-A1 | 2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF | OGFR, OPRM1, OPRD1 | HPGD 814/4885TP53 4845/4885MAPT 490/4885 |
| US-11124523-B2 | 2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof | OPRM1, OPRD1, OGFR | HPGD 1086/4885TP53 4874/4885MAPT 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.