Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | OGG1 | O15527 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28195663 | 0.78 | LMNA (0.48) | CES2CA1CA2CYP1A2LMNA | |
| SCHEMBL27274072 | 0.74 | C1S (0.57) | LMNARAB9AMAPTALDH1A1HPGD | |
| SCHEMBL3045890 | 0.73 | ALDH1A1 (0.58) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL28066941 | 0.71 | CES2 (0.48) | CES2CES1CA1CA2GSK3B | |
| Water SCHEMBL28480633 | 0.71 | ALDH1A1 (0.56) | CES2CES1CA1CA2GSK3B | |
| Formic Acid SCHEMBL27583412 | 0.70 | CYP2A6 (0.57) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL2712830 | 0.70 | CES2 (0.46) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL27986961 | 0.70 | CES2 (0.46) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL2712831 | 0.70 | CES2 (0.46) | CES2CES1CA1CA2GSK3B | |
| SCHEMBL4862898 | 0.68 | CES2 (0.44) | CES2CES1CA1CA2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163248-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |