Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 3/20 | 0.62 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.62 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.62 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.62 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.57 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | CTSG | P08311 | 1/20 | 0.56 |
| ▸ | TCF4 | P15884 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | KLHL20 | Q9Y2M5 | 1/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22342183 | 0.98 | ITGAV (0.63) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342251 | 0.95 | ITGB3 (0.64) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342253 | 0.93 | ITGB3 (0.65) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342181 | 0.93 | ITGB3 (0.61) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342257 | 0.91 | ITGAV (0.59) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342281 | 0.88 | ITGB3 (0.56) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22341394 | 0.87 | ITGB3 (0.70) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342265 | 0.86 | KEAP1 (0.62) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22342227 | 0.84 | KEAP1 (0.58) | ITGAVITGB3ITGB5ITGB1ITGA5 | |
| SCHEMBL22341445 | 0.82 | ITGAV (0.53) | ITGAVITGB3ITGB5ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | ALMIRALL SA (ES) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255478-A1 | NOVEL COMPOUNDS ACTIVATING THE NRF2 PATHWAY | KEAP1, NFE2L2, HMOX1 | ITGAV 4854/4885ITGB3 4873/4885ITGB5 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.