SCHEMBL22345592

SCHEMBL22345592

CC#Cc1cc(C)c(C2=C(OC)CC3(CCN(C(=O)OC(C)(C)C)CC3)CC2=O)c(C)c1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GPR183 P32249 1/20 0.41
ACACB O00763 5/20 0.37
MMP13 P45452 3/20 0.35
ADAM17 P78536 3/20 0.35
GPR119 Q8TDV5 6/20 0.34
MMP2 P08253 1/20 0.33
MMP14 P50281 1/20 0.33
SPR P35270 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
SCD5 Q86SK9 1/20 0.33
GRM5 P41594 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21344870 0.92 GPR183 (0.39) GPR183ACACBMMP13ADAM17GPR119
SCHEMBL22907827 0.89 GPR183 (0.33) GPR183ACACB
SCHEMBL24092256 0.87 CYP2D6 (0.34) GRM5
SCHEMBL21357431 0.86 GPR119 (0.40) GPR183ACACBGPR119SPRHDAC1
SCHEMBL21361211 0.86 ACACB (0.39) GPR183ACACBGPR119SPRHDAC1
SCHEMBL22907825 0.86 GPR183 (0.32) GPR183MMP13ADAM17
SCHEMBL24426494 0.84 ALDH1A1 (0.37) ADAM17
SCHEMBL24426581 0.82 ALDH1A1 (0.35)
SCHEMBL24426556 0.81
SCHEMBL21357462 0.81 USP30 (0.37) GPR183ACACBGPR119HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479804-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2025-11-25 US disclosed
EP-3999492-B1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-09-03 EP disclosed
US-12281081-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 US disclosed
CN-114080385-B Herbicidal compounds 先正达农作物保护股份公司 2024-08-13 CN disclosed
CN-113412256-B Herbicidal compounds 先正达农作物保护股份公司 2024-01-19 CN disclosed
EP-3924339-B1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2023-03-22 EP disclosed
US-20220259153-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-08-18 US disclosed
EP-3999492-A1 HERBICIDAL COMPOUNDS Syngenta Crop Protection AG (CH) 2022-05-25 EP disclosed
US-20220089543-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-03-24 US disclosed
CN-114080385-A Herbicidal compounds 先正达农作物保护股份公司 2022-02-22 CN disclosed
EP-3924339-A1 HERBICIDAL COMPOUNDS Syngenta Crop Protection AG (CH) 2021-12-22 EP disclosed
WO-2021009232-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed
WO-2021009232-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed
WO-2020165102-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-08-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220089543-A1 HERBICIDAL COMPOUNDS DDT, CBR3, GLRX3 GPR183 1888/4885ACACB 1336/4885MMP13 3525/4885
US-12281081-B2 Herbicidal compounds DDT, CBR3, GLRX3 GPR183 1888/4885ACACB 1336/4885MMP13 3525/4885
US-20220259153-A1 HERBICIDAL COMPOUNDS DDT, CBR3, CYP4X1 GPR183 2191/4885ACACB 1213/4885MMP13 3512/4885
US-12479804-B2 Herbicidal compounds DDT, CBR3, CYP4X1 GPR183 2191/4885ACACB 1213/4885MMP13 3512/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.