Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 15/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20268384 | 1.00 | TRPV3 (0.42) | TRPV3CD274PDCD1LG2PDCD1ROCK2 | |
| SCHEMBL20268380 | 1.00 | TRPV3 (0.42) | TRPV3CD274PDCD1LG2PDCD1ROCK2 | |
| SCHEMBL29442719 | 1.00 | TRPV3 (0.42) | TRPV3CD274PDCD1LG2PDCD1ROCK2 | |
| SCHEMBL30850026 | 1.00 | TRPV3 (0.42) | TRPV3CD274PDCD1LG2PDCD1ROCK2 | |
| SCHEMBL28634457 | 0.87 | TRPV3 (0.48) | TRPV3CD274PDCD1LG2 | |
| SCHEMBL28634455 | 0.87 | TRPV3 (0.48) | TRPV3CD274PDCD1LG2 | |
| SCHEMBL22345810 | 0.84 | TRPV3 (0.44) | TRPV3 | |
| SCHEMBL30850043 | 0.84 | TRPV3 (0.44) | TRPV3 | |
| SCHEMBL22345794 | 0.81 | GAA (0.56) | TRPV3CD274PDCD1LG2PDCD1GAA | |
| SCHEMBL22345795 | 0.81 | GAA (0.56) | TRPV3CD274PDCD1LG2PDCD1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250313573-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2025-10-09 | — | — | US | disclosed |
| US-20240352034-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2024-10-24 | — | — | US | disclosed |
| CN-118206566-A | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-06-18 | — | — | CN | disclosed |
| US-11945826-B2 | Hydroxypyridoxazepines as NRF2 activators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2024-04-02 | — | — | US | disclosed |
| CN-113474349-B | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-20220204526-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-06-30 | — | — | US | disclosed |
| EP-3924356-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2021-12-22 | — | — | EP | disclosed |
| CN-113474349-A | Hydroxypyridooxazepine heptatrienes as NRF2 activators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-10-01 | — | — | CN | disclosed |
| WO-2020165776-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204526-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | KEAP1, NFE2L2, NQO1 | TRPV3 335/4885CD274 4090/4885PDCD1LG2 3447/4885 |
| US-11945826-B2 | Hydroxypyridoxazepines as NRF2 activators | KEAP1, NFE2L2, NQO1 | TRPV3 335/4885CD274 4090/4885PDCD1LG2 3447/4885 |
| US-20250313573-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | KEAP1, NFE2L2, NQO1 | TRPV3 335/4885CD274 4090/4885PDCD1LG2 3447/4885 |
| US-20240352034-A1 | HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS | KEAP1, NFE2L2, NQO1 | TRPV3 335/4885CD274 4090/4885PDCD1LG2 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.