Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7085407 | 0.81 | MEN1 (0.35) | TSHRBLMLMNAKMT2AMEN1 | |
| Acetic Acid SCHEMBL22346335 | 0.81 | FFAR3 (0.41) | TSHRBLMLMNAKMT2AMEN1 | |
| Fumaric Acid SCHEMBL9617453 | 0.81 | TSHR (0.60) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Tromethamine SCHEMBL3358691 | 0.79 | LMNA (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Tromethamine SCHEMBL29379456 | 0.79 | LMNA (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL28968002 | 0.79 | TSHR (0.50) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Glycolic Acid SCHEMBL22346343 | 0.79 | HMGCR (0.38) | TSHRTDP1LMNAAPEX1KMT2A | |
| Fumaric Acid SCHEMBL10396296 | 0.79 | TSHR (0.50) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Tromethamine SCHEMBL4449265 | 0.79 | LMNA (0.56) | TSHRTP53EGLN1EGLN3GABRR1 | |
| Maleic Acid SCHEMBL11308587 | 0.79 | TSHR (0.50) | TSHRTP53EGLN1EGLN3GABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | MIYOSHI YUSHI KK (JP) | 2025-03-20 | — | — | US | disclosed |
| CN-113423470-B | Cosmetic compounding agent, cosmetic, and method for producing same | 三吉油脂株式会社 | 2024-07-09 | — | — | CN | disclosed |
| US-20220096349-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | MIYOSHI OIL & FAT CO., LTD. (JP) | 2022-03-31 | — | — | US | disclosed |
| EP-3925671-A1 | COSMETIC INGREDIENT, COSMETIC, AND PRODUCTION METHOD FOR COSMETIC | Miyoshi Oil & Fat Co., Ltd. (JP) | 2021-12-22 | — | — | EP | disclosed |
| CN-113423470-A | Cosmetic compounding agent, cosmetic and method for producing same | 三吉油脂株式会社 | 2021-09-21 | — | — | CN | disclosed |
| WO-2020166678-A1 | COSMETIC INGREDIENT, COSMETIC, AND PRODUCTION METHOD FOR COSMETIC | ミヨシ油脂株式会社 | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096349-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | H1-0, H1-4, H1-2 | KMT2A 1367/4885MEN1 272/4885TSHR 1053/4885 |
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | CUTA, HAT1, NACA | KMT2A 961/4885MEN1 643/4885TSHR 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.