SCHEMBL2234772

SCHEMBL2234772

CC1=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc2C1[Zr](C1C(C)=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc21)[SiH](C)C

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.32
CREBBP Q92793 1/20 0.32
NPC1 O15118 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NR1H4 Q96RI1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2232423 0.99 BRD4 (0.31) BRD4CREBBPNPC1LMNATP53
SCHEMBL22411948 0.94
SCHEMBL3700473 0.91
Hydrochloric Acid SCHEMBL2233539 0.90
SCHEMBL6459300 0.90
SCHEMBL22411218 0.89
SCHEMBL3681017 0.89 RXRA (0.30)
SCHEMBL11967835 0.88
Chloromethane SCHEMBL8460737 0.88 ENPP1 (0.32)
SCHEMBL5584002 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799726-B1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEM PATENTS INC (US) 2011-07-13 EP claimed
US-20090221772-A1 Bridged bis indenyl ligands where the indene ring is further fused to an oxygen or sulfur-containing ring, such as mu -{Bis-[ eta 5-8-(4-tert-butylphenyl)-6-methyl-5H-indeno[5,6-a][1,3]dioxol-5-yl]dimethylsilanediyl}dichlorozirconium; olefin polymerization catalysts; very high molecular weight BASELL POLYLEFINE GMBH (DE) 2009-09-03 US disclosed
EP-1549688-A2 PROCESS FOR THE COPOLYMERIZATION OF ETHYLENE Basell Polyolefine GmbH (DE) 2005-07-06 EP disclosed
WO-2004033510-A2 PROCESS FOR THE COPOLYMERIZATION OF ETHYLENE BASELL POLYOLEFINE GMBH (DE) 2004-04-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221772-A1 Bridged bis indenyl ligands where the indene ring is further fused to an oxygen or sulfur-containing ring, such as mu -{Bis-[ eta 5-8-(4-tert-butylphenyl)-6-methyl-5H-indeno[5,6-a][1,3]dioxol-5-yl]dimethylsilanediyl}dichlorozirconium; olefin polymerization catalysts; very high molecular weight LTC4S, HMOX1, OPRM1 BRD4 607/4885CREBBP 4749/4885NPC1 4474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.