SCHEMBL2235596

SCHEMBL2235596

OB(O)c1cnc(CS)nc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14552625 0.78 ENPP2 (0.35)
SCHEMBL14298936 0.76
SCHEMBL22169942 0.76 F11 (0.41)
SCHEMBL21236655 0.76 LPL (0.43)
Hydrochloric Acid SCHEMBL22165878 0.74 F11 (0.45)
SCHEMBL16576681 0.71 ESR1 (0.30)
SCHEMBL7452989 0.69 ENPP2 (0.39)
SCHEMBL5900799 0.68 RECQL (0.31) MAPTTDP1
SCHEMBL25059482 0.67 ADH1B (0.34)
SCHEMBL21469007 0.67 HDAC8 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012127212-A1 IMIDAZO [1, 2 - B] PYRIDAZINE DERIVATIVES AS CDPK1 INHIBITORS MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2012-09-27 WO disclosed
WO-2011101640-A1 FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) 2011-08-25 WO disclosed