Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR1 | P30872 | 2/20 | 0.53 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814370 | 0.79 | CNR2 (0.50) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL23228758 | 0.78 | SSTR4 (0.54) | SSTR1SSTR4PTGDR2MEN1KMT2A | |
| SCHEMBL7804397 | 0.78 | NPC1 (0.52) | PTGDR2MEN1KMT2APOLBLMNA | |
| SCHEMBL7804382 | 0.78 | MEN1 (0.67) | PTGDR2MEN1KMT2ALMNA | |
| SCHEMBL26473594 | 0.76 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL7804447 | 0.74 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL7811675 | 0.73 | KMT2A (0.58) | PTGDR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8894896 | 0.73 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL824153 | 0.73 | DRD2 (0.69) | MEN1KMT2ADRD2 | |
| SCHEMBL8893026 | 0.72 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1S1PR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488028-B1 | SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME (US) | 2020-08-19 | — | — | EP | disclosed |