Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22359943 | 0.73 | NPSR1 (0.39) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL26227380 | 0.72 | MAPT (0.51) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL20837877 | 0.65 | SMN1; SMN2 (0.37) | GAASMN1; SMN2LMNA | |
| SCHEMBL12327468 | 0.64 | SLC9A1 (0.67) | MAPTTSHRKDM4ELMNAKMT2A | |
| SCHEMBL20627141 | 0.63 | TSHR (0.47) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL13610401 | 0.63 | KDM4E (0.60) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL15113583 | 0.61 | MEN1 (0.49) | MAPTGAAKDM4EKMT2AMEN1 | |
| SCHEMBL28666665 | 0.61 | DRD2 (0.44) | HTR1AHTR6 | |
| SCHEMBL23586698 | 0.61 | MAPT (0.51) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL19848484 | 0.61 | KDM4E (0.49) | MAPTNPSR1HPGDGAACCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423443-B1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2020-08-19 | — | — | EP | disclosed |