Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22942049 | 0.73 | MAPT (0.43) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL22359797 | 0.72 | MAPT (0.40) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL21736972 | 0.71 | KCNMA1 (0.48) | NPSR1TSHRSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL27303109 | 0.71 | MAPT (0.46) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL12204504 | 0.70 | SLC9A1 (0.54) | TSHRSMN1; SMN2KCNMA1SLC9A1 | |
| SCHEMBL12204509 | 0.70 | KCNMA1 (0.47) | NPSR1TSHRSMN1; SMN2KDM4ELMNA | |
| SCHEMBL23762162 | 0.70 | SLC9A1 (0.49) | MAPTNPSR1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL17355083 | 0.69 | NPSR1 (0.54) | MAPTNPSR1HPGDGAACCR6 | |
| SCHEMBL21467623 | 0.69 | RAB9A (0.46) | MAPTNPSR1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL13610401 | 0.69 | KDM4E (0.60) | MAPTNPSR1HPGDGAACCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3604308-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2023-09-13 | — | — | EP | disclosed |