SCHEMBL2236039

SCHEMBL2236039

CCCCOC(=O)NC(CC(=O)OCc1ccccc1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.53
CTSS P25774 2/20 0.53
ALDH1A1 P00352 1/20 0.52
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
MAPK1 P28482 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
SIRT2 Q8IXJ6 1/20 0.52
SIRT1 Q96EB6 1/20 0.52
ITGB3 P05106 7/20 0.50
ITGA2B P08514 7/20 0.50
CTSK P43235 6/20 0.49
CAPN1 P07384 1/20 0.48
CAPN2 P17655 1/20 0.48
CASP1 P29466 1/20 0.48
MBOAT4 Q96T53 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4763048 1.00 CTSL (0.53) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL7408222 1.00 CTSL (0.53) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL12062829 0.95 CTSL (0.56) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL4726420 0.95 CTSL (0.56) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL8298775 0.95 CTSL (0.56) CTSLCTSSALDH1A1CYP3A4TSHR
Water SCHEMBL4982047 0.94 CTSL (0.57) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL7423094 0.92 SIRT2 (0.53) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL2026644 0.89 SIRT2 (0.52) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL18954330 0.88 ALDH1A1 (0.58) CTSLCTSSALDH1A1CYP3A4TSHR
SCHEMBL7583002 0.87 CASP1 (0.60) CTSLCTSSALDH1A1CTSKCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2534152-A1 MACROCYCLES AS FACTOR XIA INHIBITORS Bristol-Myers Squibb Company (US) 2012-12-19 EP disclosed
EP-2534154-A1 MACROCYCLES AS FACTOR XIA INHIBITORS Bristol-Myers Squibb Company (US) 2012-12-19 EP disclosed
WO-2011100402-A1 MACROCYCLES AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-08-18 WO disclosed
WO-2011100401-A1 MACROCYCLES AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2011-08-18 WO disclosed
WO-2002039997-A2 ACE-2 MODULATING COMPOUNDS AND USE THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2002-05-23 WO disclosed