Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23891647 | 0.82 | THRA (0.41) | IDO1KMT2AATMSLC6A2SLC6A4 | |
| SCHEMBL20683682 | 0.81 | RAB9A (0.41) | KMT2ACES2MRGPRX4 | |
| SCHEMBL26854405 | 0.80 | PDE3B (0.44) | IDO1KMT2AATMHCRTR1HCRTR2 | |
| SCHEMBL2028898 | 0.79 | KMT2A (0.46) | IDO1KMT2AATMHCRTR1HCRTR2 | |
| SCHEMBL20669464 | 0.78 | IDO1 (0.41) | IDO1KMT2AATMHCRTR1HCRTR2 | |
| SCHEMBL3340113 | 0.78 | CES2 (0.50) | CES2CES1 | |
| SCHEMBL18463980 | 0.77 | LMNA (0.46) | — | |
| SCHEMBL20179628 | 0.75 | HPGD (0.41) | KMT2ASLC6A2SLC6A4P2RX7 | |
| SCHEMBL25902683 | 0.73 | THRA (0.47) | IDO1KMT2AATMHCRTR1HCRTR2 | |
| SCHEMBL27485011 | 0.73 | IDO1 (0.39) | IDO1KMT2AATMHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3434668-B1 | INDOLO-SUBSTITUTED-PIPERIDINE COMPOUNDS AS ESTROGEN RECEPTOR DEGRADING AGENT | LUOXIN PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2020-08-26 | — | — | EP | disclosed |