Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.44 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22319963 | 1.00 | CTSL (0.46) | CTSLCTSBCTSKCHRNB2CHRNA4 | |
| SCHEMBL22616969 | 0.92 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNA4 | |
| SCHEMBL22616971 | 0.92 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNA4 | |
| SCHEMBL22616980 | 0.92 | CTSL (0.53) | CTSLCTSBCTSKCHRNB2CHRNA4 | |
| SCHEMBL3356243 | 0.86 | TEAD3 (0.47) | CTSKCHRNB2CHRNA4TEAD3HSD11B1 | |
| SCHEMBL3356236 | 0.86 | TEAD3 (0.47) | CTSKCHRNB2CHRNA4TEAD3HSD11B1 | |
| SCHEMBL3356619 | 0.86 | TEAD3 (0.47) | CTSKCHRNB2CHRNA4TEAD3HSD11B1 | |
| SCHEMBL25383877 | 0.86 | HTR6 (0.50) | BCHE | |
| SCHEMBL5237806 | 0.85 | SMN1; SMN2 (0.51) | CTSLCTSBCTSKCHRNB2CHRNA4 | |
| SCHEMBL5229819 | 0.81 | HTR6 (0.50) | BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |