⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825204 | 0.71 | GABRA1 (0.32) | — | |
| SCHEMBL26613976 | 0.69 | S1PR1 (0.39) | — | |
| SCHEMBL28756736 | 0.68 | HTT (0.41) | — | |
| SCHEMBL3286549 | 0.66 | — | — | |
| SCHEMBL28621045 | 0.66 | — | — | |
| SCHEMBL22367353 | 0.66 | ALPL (0.33) | — | |
| SCHEMBL20320618 | 0.65 | — | — | |
| SCHEMBL22367354 | 0.64 | AGBL2 (0.36) | — | |
| SCHEMBL20320474 | 0.63 | NOS3 (0.33) | — | |
| SCHEMBL17548461 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11242344-B2 | (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof | GENENTECH, INC. (US) | 2022-02-08 | — | — | US | disclosed |
| US-20210309660-A1 | (4-HYDROXYPYRROLIDIN-2-YL)-HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2021-10-07 | — | — | US | disclosed |
| EP-3700901-A1 | (4-HYDROXYPYRROLIDIN-2-YL)-HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |