Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22369288 | 0.82 | CA2 (0.52) | SNCASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10773023 | 0.81 | TSHR (0.61) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL27576014 | 0.74 | TAAR1 (0.66) | SMN1; SMN2ALDH1A1TP53TSHRLMNA | |
| SCHEMBL11996396 | 0.71 | SMN1; SMN2 (0.68) | SNCASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11996395 | 0.71 | SMN1; SMN2 (0.68) | SNCASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL27738081 | 0.71 | MMP1 (0.49) | SMN1; SMN2NPC1RAB9AMAPTEGFR | |
| 4-Methoxy-Cinnamanilide SCHEMBL14375152 | 0.71 | MMP1 (0.89) | SMN1; SMN2NPC1RAB9AMAPTEGFR | |
| Anethole SCHEMBL28374080 | 0.70 | CYP3A4 (0.77) | NPC1RAB9AMAPTALDH1A1TP53 | |
| Anethole SCHEMBL28374081 | 0.70 | CYP3A4 (0.77) | NPC1RAB9AMAPTALDH1A1TP53 | |
| SCHEMBL11106394 | 0.70 | RAB9A (0.85) | SMN1; SMN2NPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |