Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19538924 | 0.75 | GPR3 (0.56) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL10235160 | 0.75 | ALDH1A1 (0.66) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL19539157 | 0.74 | KDM4E (0.60) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL17673147 | 0.74 | KDM4E (0.49) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL19531696 | 0.71 | KDM4E (0.47) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL1240359 | 0.69 | ALDH1A1 (0.47) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL18730762 | 0.69 | KDM4E (0.44) | EGFRKDM4EHTTCYP1A2CYP2D6 | |
| SCHEMBL797469 | 0.66 | KDM4E (0.67) | KDM4EHTTCYP1A2CYP2D6SLC2A1 | |
| SCHEMBL1925036 | 0.66 | GPR3 (0.58) | EGFRKDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7710952 | 0.66 | KDM4E (0.58) | EGFRKDM4EHTTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |