Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389986 | 0.71 | HPGD (0.57) | MT-CO2MAPK14HPGDHTTLMNA | |
| SCHEMBL22369197 | 0.69 | CREBBP (0.53) | CREBBPBRD4HPGDKDM4EALDH1A1 | |
| SCHEMBL26605330 | 0.67 | HPGD (0.57) | MT-CO2MAPK14HPGDHTTLMNA | |
| SCHEMBL22368655 | 0.67 | BRD4 (0.61) | CREBBPBRD4HPGDROCK2 | |
| SCHEMBL6358813 | 0.66 | MT-CO2 (0.65) | MT-CO2HPGDLMNAL3MBTL1KDM4E | |
| SCHEMBL5723909 | 0.65 | HPGD (0.67) | HPGDHTTLMNAGAAALDH1A1 | |
| SCHEMBL30646449 | 0.65 | HPGD (0.67) | HPGDHTTLMNAGAAALDH1A1 | |
| SCHEMBL22368855 | 0.63 | CREBBP (0.60) | MAPK14CREBBPLMNAKDM4EDRD3 | |
| SCHEMBL22368804 | 0.61 | CREBBP (0.62) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL6981714 | 0.61 | KMT2A (0.51) | CREBBPHPGDLMNAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |