Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.53 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680984 | 0.86 | CREBBP (0.70) | CREBBPBRD4HPGD | |
| SCHEMBL22368655 | 0.76 | BRD4 (0.61) | CREBBPBRD4HPGD | |
| SCHEMBL16088694 | 0.73 | HTT (0.58) | HPGDLIPGKDM4EALDH1A1RCE1 | |
| SCHEMBL16127844 | 0.72 | HPGD (0.57) | HPGDLIPGKDM4EALDH1A1RCE1 | |
| SCHEMBL22368804 | 0.71 | CREBBP (0.62) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL17680982 | 0.71 | CREBBP (0.64) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL22369195 | 0.69 | MT-CO2 (0.44) | CREBBPBRD4HPGDKDM4EALDH1A1 | |
| SCHEMBL17673184 | 0.69 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680977 | 0.69 | CREBBP (0.68) | CREBBPBRD4HPGDKDM4EALDH1A1 | |
| SCHEMBL1963128 | 0.68 | CRBN (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |