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SCHEMBL22380992

SCHEMBL22380992

COc1ccc(CNc2c(F)c(F)c(F)c(F)c2S(N)(=O)=O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 13/20 1.00
▸ CA1 P00915 12/20 1.00
▸ CA12 O43570 8/20 1.00
▸ CA9 Q16790 7/20 1.00
▸ CA7 P43166 5/20 1.00
▸ CA13 Q8N1Q1 4/20 1.00
▸ CA4 P22748 2/20 0.47
▸ HTT P42858 1/20 0.43
▸ CA5A P35218 1/20 0.43
▸ CA14 Q9ULX7 1/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ MAPK1 P28482 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31124350 0.93 CA2 (0.87) CA2CA1CA12CA9CA7
SCHEMBL29671248 0.84 CA12 (0.73) CA2CA1CA12CA9CA7
SCHEMBL22909494 0.84 CA12 (0.73) CA2CA1CA12CA9CA7
SCHEMBL29095322 0.77 CA2 (0.62) CA2CA1CA12CA9CA7
SCHEMBL30648574 0.76 CA12 (0.61) CA2CA1CA12CA9CA7
SCHEMBL22909166 0.76 CA12 (0.60) CA2CA1CA12CA9CA7
SCHEMBL29671241 0.76 CA12 (0.60) CA2CA1CA12CA9CA7
SCHEMBL19364394 0.74 CA2 (0.72) CA2CA1CA12CA9CA7
SCHEMBL15648241 0.74 CA2 (1.00) CA2CA1CA12CA9CA7
SCHEMBL28762097 0.72 CA12 (0.56) CA2CA1CA12CA9CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230149403-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-05-18 — — US disclosed
US-20230149403-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-05-18 — — US disclosed
US-20210052590-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2021-02-25 — — US disclosed
US-10758537-B2 Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type 2 inflammation RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2020-09-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10758537-B2 Carbonic anhydrase enzymes for regulating mast cell hematopoiesis and type 2 inflammation CA2, CMA1, CPA3 CA2 1/4885CA1 10/4885CA12 8/4885
US-20230149403-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION CA2, CMA1, CPA3 CA2 1/4885CA1 10/4885CA12 8/4885
US-20210052590-A1 CARBONIC ANHYDRASE ENZYMES FOR REGULATING MAST CELL HEMATOPOIESIS AND TYPE 2 INFLAMMATION CA2, CMA1, CPA3 CA2 1/4885CA1 10/4885CA12 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.