Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 2/20 | 0.64 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.64 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.55 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237845 | 0.90 | LMNA (0.63) | TCF4CTNNB1PFKFB3PFKFB4CYP19A1 | |
| SCHEMBL2234325 | 0.89 | CYP19A1 (0.56) | CYP19A1POLBNPC1MAPTRAB9A | |
| SCHEMBL2235467 | 0.88 | POLB (0.70) | PFKFB3PFKFB4CYP19A1POLBMAPT | |
| SCHEMBL2234339 | 0.88 | CYP19A1 (0.57) | TCF4CTNNB1CYP19A1POLBMAPT | |
| SCHEMBL10093377 | 0.87 | CYP19A1 (0.53) | TCF4CTNNB1CYP19A1POLBMAPT | |
| SCHEMBL10093407 | 0.87 | ATIC (0.58) | TCF4CTNNB1CYP19A1POLBMAPT | |
| SCHEMBL2236890 | 0.86 | CYP19A1 (0.52) | TCF4CTNNB1CYP19A1POLBMAPT | |
| SCHEMBL15232983 | 0.81 | CYP19A1 (0.57) | CYP19A1MAPTGPR27IDH1LMNA | |
| SCHEMBL10093371 | 0.80 | TCF4 (0.64) | TCF4CTNNB1PFKFB3PFKFB4POLB | |
| SCHEMBL2236105 | 0.80 | CYP19A1 (0.58) | CYP19A1POLBMAPTGPR27BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349990-B1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | PIMCO 2664 LTD (GB) | 2018-05-02 | — | — | EP | disclosed |
| US-8207167-B2 | Aryl-phenyl-sulfonamide-phenylene compounds and their use | PIMCO 2664 LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| US-20110190302-A1 | Aryl-Phenyl-Sulfonamide-Phenylene Compounds and Their Use | PIMCO 2664 LIMITED (GB) | 2011-08-04 | — | — | US | disclosed |
| EP-2349990-A1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | Pimco 2664 Limited (GB) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010032010-A1 | ARYL-PHENYL-SULFONAMIDE-PHENYLENE COMPOUNDS AND THEIR USE | PIMCO 2664 LIMITED (GB) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190302-A1 | Aryl-Phenyl-Sulfonamide-Phenylene Compounds and Their Use | SOST, PSAP, ARSA | TCF4 1323/4885CTNNB1 1732/4885PFKFB3 1573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.