Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2238197 | 1.00 | MAPT (0.46) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL2236227 | 0.89 | RAB9A (0.49) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL2236225 | 0.89 | RAB9A (0.49) | MAPTRAB9AKDM4ENPC1JUN | |
| Trifluoroacetic Acid SCHEMBL2238726 | 0.85 | JUN (0.41) | MAPTKDM4EJUNNFKB1MAPK1 | |
| Trifluoroacetic Acid SCHEMBL2238735 | 0.85 | JUN (0.41) | MAPTKDM4EJUNNFKB1MAPK1 | |
| SCHEMBL2238194 | 0.79 | RAB9A (0.44) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL2238193 | 0.79 | RAB9A (0.44) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL2243228 | 0.75 | MAPT (0.47) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL1936081 | 0.75 | MAPT (0.47) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL5236707 | 0.74 | OPRM1 (0.42) | MAPTCYP1A2CYP1B1CYP2D6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MAPT 2733/4885RAB9A 2719/4885KDM4E 2806/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MAPT 2466/4885RAB9A 2507/4885KDM4E 2968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.