Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 11/20 | 0.42 |
| ▸ | SORD | Q00796 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19903044 | 0.88 | GBA1 (0.53) | GBA1HCRTR1HCRTR2 | |
| SCHEMBL19894036 | 0.74 | HCRTR1 (0.41) | GBA1HCRTR1HCRTR2KDM4EHSD17B10 | |
| SCHEMBL19903051 | 0.71 | HSD17B10 (0.43) | GBA1SORDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19894035 | 0.71 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL22383535 | 0.69 | HCRTR1 (0.44) | GBA1SORDHCRTR1HCRTR2 | |
| SCHEMBL14872339 | 0.69 | CRHBP (0.59) | GBA1SORDKDM4EALDH1A1HPGD | |
| SCHEMBL19894018 | 0.67 | HCRTR1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL19903143 | 0.67 | MEN1 (0.41) | GBA1SORDALDH1A1NPSR1MAPK1 | |
| SCHEMBL19894101 | 0.66 | HCRTR1 (0.53) | HCRTR1HCRTR2KDM4EHSD17B10 | |
| SCHEMBL5790244 | 0.66 | SMN1; SMN2 (0.65) | GBA1SORDKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287454-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |