SCHEMBL2238587

SCHEMBL2238587

CCOC(=O)CCON(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
LTA4H P09960 5/20 0.48
LMNA P02545 2/20 0.48
HSD17B10 Q99714 2/20 0.48
ALDH1A1 P00352 2/20 0.48
POLB P06746 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
TDP1 Q9NUW8 2/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 1/20 0.46
ABCB1 P08183 1/20 0.45
MAPK1 P28482 2/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
PPID Q08752 1/20 0.44
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2241139 0.85 TDP1 (0.51) ALOX5SMN1; SMN2LTA4HLMNAHSD17B10
SCHEMBL10351423 0.85 TSHR (0.48) LTA4HLMNAHSD17B10ALDH1A1POLB
SCHEMBL562070 0.84 KDM4E (0.49) LTA4HLMNAALDH1A1POLBL3MBTL1
SCHEMBL10352510 0.84 TDP1 (0.46) ALOX5SMN1; SMN2LMNAHSD17B10ALDH1A1
SCHEMBL7920783 0.80 KEAP1 (0.48) ALOX5SMN1; SMN2LMNAHSD17B10TDP1
SCHEMBL561596 0.79 KEAP1 (0.47) ALOX5SMN1; SMN2LMNAHSD17B10TDP1
SCHEMBL1140947 0.78 SMN1; SMN2 (0.55) ALOX5SMN1; SMN2LTA4HLMNAHSD17B10
SCHEMBL9324850 0.78 SMN1; SMN2 (0.55) ALOX5SMN1; SMN2LTA4HLMNAHSD17B10
SCHEMBL1303146 0.77 LTA4H (0.62) ALOX5SMN1; SMN2LTA4HLMNAHSD17B10
Potassium Ion SCHEMBL561597 0.76 HDAC3 (0.46) ALOX5SMN1; SMN2LMNAHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0240462-B1 SUBSTITUTED AMINOOXYPROPANOATE CIBA-GEIGY AG (CH) 1990-08-01 EP claimed
EP-0240462-A2 Substituted aminooxypropanoate CIBA-GEIGY AG (CH) 1987-10-07 EP claimed
EP-1885787-B1 PHOSPHITE ADDITIVES IN POLYOLEFINS PHILLIPS PETROLEUM CO (US) 2018-01-10 EP disclosed
US-8258215-B2 Mixed alkyl-alkylaryl-phenyl phosphite polymer additive DOVER CHEMICAL CORPORATION (US) 2012-09-04 US disclosed
US-8188170-B2 Polymers with low gel content and enhanced gas-fading CHEMTURA CORPORATION (US) 2012-05-29 US disclosed
US-20110196079-A1 Mixed alkyl-alklaryl-phenyl phosphite polymer additive DOVER CHEMICAL CORPORATION (US) 2011-08-11 US disclosed
US-20100197837-A1 POLYMERS WITH LOW GEL CONTENT AND ENHANCED GAS-FADING CHEMTURA CORPORATION (US) 2010-08-05 US disclosed
EP-1692150-A4 PROCESS FOR MANUFACTURE OF PENTAERYTHRITOL DIPHOSPHITES DOVER CHEMICAL CORP (US) 2009-02-25 EP disclosed
US-7470735-B2 Phenol-free phosphites DOVER CHEMICAL CORPORATION (US) 2008-12-30 US disclosed
US-7342060-B2 Process for manufacture of pentaerythritol diphosphites DOVER CHEMICAL CORPORATION (US) 2008-03-11 US disclosed
US-7157511-B2 Phosphite additives in polyolefins CHEVRON PHILLIPSCHEMICAL COMPANY LP 2007-01-02 US disclosed
US-5438086-A High thermal decomposition temperature, resists yellowing; polyolefin antioxidants THE HUNTINGTON NATIONAL BANK 1995-08-01 US disclosed
WO-1995006651-A1 HYDROLYTICALLY STABLE PENTAERYTHRITOL DIPHOSPHITES DOVER CHEMICAL CORPORATION (US) 1995-03-09 WO disclosed
EP-0356687-B1 Bis (tri-tertiary-alkylphenoxy) diphosphaspiroundecanes GE SPECIALTY CHEM (US) 1994-06-22 EP disclosed
US-5308901-A Oxidation resistant, photostabilizers for polymers GENERAL ELECTRIC COMPANY (US) 1994-05-03 US disclosed
US-5137950-A Reacting phosphorous trichloride with alcohol; polymer stabilizer BORG-WARNER SPECIALTY CHEMICALS, INC. (US) 1992-08-11 US disclosed
US-5023285-A Melt flow and color stabilizers for polymers G E SPECIALTY CHEMICALS (US) 1991-06-11 US disclosed
EP-0240462-B1 SUBSTITUTED AMINOOXYPROPANOATE CIBA-GEIGY AG (CH) 1990-08-01 EP disclosed
EP-0356687-A1 Bis (tri-tertiary-alkylphenoxy) diphosphaspiroundecanes GE SPECIALTY CHEMICALS, INC. (US) 1990-03-07 EP disclosed
EP-0240462-A2 Substituted aminooxypropanoate CIBA-GEIGY AG (CH) 1987-10-07 EP disclosed